Description

1-(6-Aminohexyl)-1H-Pyrrole-2,5-Dione is a versatile bifunctional chemical building block featuring both a primary amine and a maleimide group. This compound is critical for researchers and manufacturers requiring precise, covalent conjugation strategies in advanced material and life science applications. It is primarily utilized by professionals in the pharmaceutical, bioconjugation, and polymer science industries for creating stable, functionalized linkages.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, antibodies, and peptides via the maleimide-thiol reaction.
• Polymer Modification: As a functional monomer or crosslinker to introduce amine-reactive sites into polymer backbones for advanced material synthesis.
• Surface Functionalization: For coating and modifying surfaces (e.g., nanoparticles, biosensors, chromatography media) to create amine-reactive platforms.
• Linker Chemistry: Serving as a heterobifunctional crosslinker (spacer arm ~11.4 Å) for constructing drug conjugates, such as Antibody-Drug Conjugates (ADCs).
• Diagnostic Assay Development: In the preparation of enzyme conjugates and labeled probes for immunoassays and histochemistry.
• Hydrogel Formation: As a crosslinking agent in the development of biocompatible hydrogels for drug delivery and tissue engineering.

Basic Information

Product Name	1-(6-Aminohexyl)-1H-Pyrrole-2,5-Dione
CAS No.	121663-74-9
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	6-Maleimidohexylamine; N-(6-Aminohexyl)maleimide; 1H-Pyrrole-2,5-dione, 1-(6-aminohexyl)-; Maleimidocaproylamine; 6-Aminohexyl maleimide; N-(6-Aminohexyl)maleimide; 6-Maleimidocaproic acid amine; AMH
EINECS	Contact for details

Quality Control

Our 1-(6-Aminohexyl)-1H-Pyrrole-2,5-Dione is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.