Description

Rac Ibuprofen-D3 CAS NO 121662-14-4 is a deuterated analog of the widely used non-steroidal anti-inflammatory drug (NSAID) ibuprofen, where three hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology, where precise quantification of ibuprofen and its metabolites is required.

Application

• Internal Standard for Bioanalytical Assays: Primary use as a deuterated internal standard in LC-MS/MS and GC-MS methods for the quantification of ibuprofen in biological matrices (plasma, serum, urine).
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in both preclinical and clinical research.
• Forensic and Clinical Toxicology: Supports reliable identification and quantification of ibuprofen in cases of overdose or for therapeutic drug monitoring.
• Pharmaceutical Quality Control: Used in analytical method development and validation to ensure the potency and purity of ibuprofen-containing drug products.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as a spike for this highly accurate analytical technique, minimizing matrix effects and improving data precision.
• Environmental Analysis: Can be employed as a tracer in studies investigating the environmental fate and transport of pharmaceutical pollutants.

Basic Information

Product Name	Rac Ibuprofen-D3
CAS No.	121662-14-4
Molecular Formula	C13H15D3O2
Molecular Weight	209.30 g/mol
Synonyms	(±)-2-(4-Isobutylphenyl)propionic-3,3,3-d3 Acid; Ibuprofen-d3; DL-Ibuprofen-d3; rac-Ibuprofen-d3; 2-[4-(2-Methylpropyl)phenyl]propionic-3,3,3-d3 Acid; (±)-Ibuprofen-3,3,3-d3; Ibuprofen (phenyl-d3); Ibuprofen (methyl-d3)
EINECS	Contact for details

Quality Control

Our Rac Ibuprofen-D3 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as a certified reference material. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC, to confirm chemical identity, isotopic purity (deuterium incorporation), and chemical purity. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for assay, isotopic enrichment, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.