Description

Fmoc-Nle-Opfp CAS NO 121593-77-9 is a specialized, high-purity amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). Its core value lies in enabling the efficient and controlled incorporation of the non-proteinogenic amino acid norleucine (Nle) into complex peptide sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostic agents, and biochemical tools. The Fmoc protecting group offers orthogonal deprotection, while the Opfp ester provides excellent reactivity for coupling reactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the stepwise assembly of custom peptides on resin supports.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormone analogs and antimicrobial peptides.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides with fluorophores, biotin, or other functional groups.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: A fundamental tool for studying protein structure-function relationships and peptide interactions.
• Production of Reference Standards: Serves as a high-purity starting material for synthesizing certified peptide standards.

Basic Information

Product Name	Fmoc-Nle-Opfp
CAS No.	121593-77-9
Molecular Formula	C₂₇H₂₀F₅NO₅
Molecular Weight	533.45 g/mol
Synonyms	Fmoc-Norleucine-Opfp; N-(9-Fluorenylmethoxycarbonyl)-L-norleucine pentafluorophenyl ester; Fmoc-L-Nle-OPfp; Fmoc-Nle-OPfp ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-L-2-Aminohexanoic acid Opfp ester; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Nle-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against our stringent in-house specifications. We support cGMP-compliant manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is both light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.