Description

5-Bromo-2-Iodobenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique bifunctional halogenated structure makes it an indispensable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for its role in cross-coupling reactions and as a precursor to various functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications via Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides, where the bromo and iodo substituents allow for precise structural modifications.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of advanced organic electronic materials, including charge-transport molecules and emissive layers for displays and lighting.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in homogeneous catalysis.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new organic reactions and constructing complex heterocyclic compounds.
• Polymer Modification: Used to introduce halogenated aromatic units into polymer backbones to alter physical properties like thermal stability and refractive index.

Basic Information

Product Name	5-Bromo-2-Iodobenzonitrile
CAS No.	121554-10-7
Molecular Formula	C7H3BrIN
Molecular Weight	307.92 g/mol
Synonyms	2-Iodo-5-bromobenzonitrile; Benzonitrile, 5-bromo-2-iodo-; 5-Bromo-2-iodobenzonitrile; 2-Cyano-4-bromo-1-iodobenzene; 4-Bromo-2-iodobenzonitrile; 1-Bromo-4-cyano-2-iodobenzene; 5-Bromo-2-iodo-benzonitrile; 121554-10-7
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Iodobenzonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed impurity profiling available. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing results for identity, assay, and related substances. Specifications can be developed to meet GMP or other stringent regulatory requirements for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to prevent decomposition. Keep the container sealed to minimize contact with moisture and atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.