Description

Boc-Glycine N,o-Dimethylhydroxamide is a protected amino acid derivative, specifically a glycine hydroxamate, featuring tert-butoxycarbonyl (Boc) and N,O-dimethyl protecting groups. This compound serves as a crucial specialty building block in advanced organic synthesis, enabling the controlled introduction of glycine units in complex molecular architectures. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of peptide mimetics, enzyme inhibitors, and novel bioactive compounds.

Application

• Peptidomimetic Synthesis: A key intermediate for constructing peptide analogs and inhibitors where the hydroxamate moiety mimics a peptide bond or acts as a metal-chelating pharmacophore.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, particularly those targeting metalloproteases like MMPs or histone deacetylases (HDACs).
• Chemical Biology Probes: Serves as a building block for creating activity-based probes to study enzyme function and mechanism.
• Custom Peptide Production: Employed in solid-phase and solution-phase peptide synthesis (SPPS) for introducing modified glycine residues.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, bioactive molecules for crop protection.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Item	Details
Product Name	Boc-Glycine N,o-Dimethylhydroxamide
CAS No.	121505-93-9
Molecular Formula	C9H18N2O4
Molecular Weight	218.25 g/mol
Synonyms	N-(tert-Butoxycarbonyl)glycine N,O-dimethylhydroxamic acid; Boc-Gly-ON(Me)OMe; (tert-Butoxycarbonyl)glycine N,O-dimethylhydroxamate; N-Boc-glycine N,O-dimethylhydroxamic acid; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, N,2-dimethyl-2-hydroxyhydrazide; Boc-Gly-N(OMe)Me; 2-[(tert-Butoxycarbonyl)amino]-N-methoxy-N-methylacetamide
EINECS	Contact for details

Quality Control

Our Boc-Glycine N,o-Dimethylhydroxamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.