Description

Endothelin (16-21) is a bioactive peptide fragment derived from the potent vasoconstrictor endothelin-1. This specific sequence is crucial for research into cardiovascular physiology and the development of receptor antagonists. It serves as a valuable tool for scientists and pharmaceutical developers investigating hypertension, vascular diseases, and related signaling pathways. The compound is supplied to ensure high purity and batch-to-batch consistency for reliable experimental results.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of endothelin receptor binding, signal transduction, and vascular biology.
• Pharmacological Development: Serves as a key intermediate or reference compound in the screening and development of novel endothelin receptor antagonists for therapeutic applications.
• In Vitro Assays: Employed in cell-based assays and biochemical tests to study the effects of endothelin fragments on cellular function and receptor activity.
• Academic Research: Utilized in university and institutional labs for fundamental research into the role of endothelin in cardiovascular and renal systems.
• Diagnostic Tool Development: Acts as a component in the development of diagnostic kits and assays aimed at detecting or quantifying endothelin-related activity.

Basic Information

Product Name	Endothelin (16-21)
CAS No.	121377-67-1
Molecular Formula	C34H51N9O10S2
Molecular Weight	809.96 g/mol
Synonyms	Endothelin-1 (16-21); ET-1 (16-21); H-Cys-Val-Tyr-Phe-Cys-His-OH (disulfide bridge: Cys1-Cys15); Endothelin-1 fragment 16-21; [Cys1,15]-Endothelin-1(16-21); Cyclo(1-15)[Cys1,Cys15]endothelin-1(16-21); CVYFCH (cyclic)
EINECS	Contact for details

Quality Control

Our Endothelin (16-21) is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Assessed by receptor binding assay (COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.