Description

(R)-3,3,3-Trifluoro-2-Hydroxypropionic Acid CAS NO 121250-04-2 is a high-value, chiral trifluoromethylated building block essential for introducing the trifluoromethyl group into complex molecules. This compound is critical for modulating the lipophilicity, metabolic stability, and bioavailability of target compounds in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drugs, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties.
• Peptide Modification: Used to incorporate fluorinated amino acid analogs into peptides to study structure-activity relationships.
• Diagnostic Agent Precursor: Acts as a building block for potential imaging agents and probes in medical diagnostics.

Basic Information

Product Name	(R)-3,3,3-Trifluoro-2-Hydroxypropionic Acid
CAS No.	121250-04-2
Molecular Formula	C3H3F3O3
Molecular Weight	144.05 g/mol
Synonyms	(R)-3,3,3-Trifluoro-2-hydroxypropanoic acid; (R)-2-Hydroxy-3,3,3-trifluoropropionic acid; D-3,3,3-Trifluoro-2-hydroxypropionic acid; (R)-TFLHA; (2R)-3,3,3-Trifluoro-2-hydroxypropanoic acid; (R)-Trifluorolactic acid; (R)-α-Hydroxy-β,β,β-trifluoropropionic acid
EINECS	Contact for details

Quality Control

Our (R)-3,3,3-Trifluoro-2-Hydroxypropionic Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.