Description

(3R,4S)-tert-Butyl 3-Amino-4-Methoxypyrrolidine-1-Carboxylate is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling precise control over the final product's biological and physical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical industry, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and infectious diseases.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel chiral ligands and organocatalysts for enantioselective synthesis.
• Peptidomimetics & Bioactive Molecule Construction: The protected amino and methoxy groups make it ideal for constructing pyrrolidine-based scaffolds found in many bioactive compounds and peptidomimetics.
• Agrochemical Research: Employed in the research and development of new, stereospecific agrochemicals and plant protection agents.
• Academic & Process Chemistry R&D: Serves as a valuable starting material in academic research and process development for route scouting and optimization.

Basic Information

Product Name	(3R,4S)-tert-Butyl 3-Amino-4-Methoxypyrrolidine-1-Carboxylate
CAS No.	121242-20-4
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	1-Boc-3-amino-4-methoxypyrrolidine (3R,4S)-; (3R,4S)-1-(tert-Butoxycarbonyl)-3-amino-4-methoxypyrrolidine; tert-Butyl (3R,4S)-3-amino-4-methoxypyrrolidine-1-carboxylate; (3R,4S)-3-Amino-4-methoxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; (3R,4S)-Boc-3-Amino-4-methoxypyrrolidine; (3R-cis)-1-(1,1-Dimethylethyl) 3-amino-4-methoxy-1-pyrrolidinecarboxylate; (3R,4S)-3-Amino-4-methoxypyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (3R,4S)-tert-Butyl 3-Amino-4-Methoxypyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.