Description

Endothelin 1, Ala(1,15)- is a synthetic, site-specific analogue of the potent vasoconstrictor peptide Endothelin-1, designed for advanced biochemical and pharmacological research. This modified peptide is critical for investigating the structure-activity relationships of endothelin receptors and their role in cardiovascular physiology and disease. It is an essential tool for researchers in pharmaceutical development, academic institutions, and contract research organizations focused on hypertension, pulmonary arterial hypertension, and related vascular disorders.

Application

• Biochemical Research: Used as a selective ligand to study endothelin receptor subtypes (ETA and ETB) and their downstream signaling pathways.
• Pharmacology & Drug Discovery: Serves as a reference standard and a key reagent in high-throughput screening assays for the development of novel endothelin receptor antagonists.
• Cardiovascular Disease Modeling: Employed in in vitro and in vivo studies to model vasoconstriction, vascular remodeling, and hypertension.
• Academic & Institutional Research: A fundamental tool for university and institutional labs exploring vascular biology, peptide chemistry, and molecular pharmacology.
• Contract Research Organization (CRO) Services: Supplied as a high-purity, well-characterized material for client-sponsored research and pre-clinical testing.

Basic Information

Product Name	Endothelin 1, Ala(1,15)-
CAS No.	121185-72-6
Molecular Formula	C109H159N27O33S5
Molecular Weight	2490.0 g/mol (approx.)
Synonyms	Ala1,15-Endothelin-1; [Ala1,15]-ET-1; Endothelin-1 (Ala1,15); [Ala1,Ala15]-Endothelin-1; Endothelin-1, [1,15-dialanine]; ET-1 (1-15 Ala); H-Ala-Ser-Ser-Cys-Ser-Cys-Asn-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bridges: Cys3-Cys11, Cys10-Cys15)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Endothelin 1, Ala(1,15)- is characterized using advanced analytical techniques to confirm identity, purity, and biological activity. Certificates of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) data are available upon request. We adhere to strict quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.