Description

3-Hydroxy Repaglinide is a key pharmaceutical intermediate and metabolite of the anti-diabetic drug repaglinide. This compound is essential for research and development in metabolic disease studies and for the synthesis of related therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories focused on diabetes treatment and drug metabolism.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of repaglinide and its structural analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism and efficacy of repaglinide.
• Impurity Profiling: Serves as a known impurity standard for HPLC and LC-MS analysis to ensure the purity of repaglinide API (Active Pharmaceutical Ingredient).
• Biochemical Research: Used in in-vitro studies to investigate mechanisms of action related to insulin secretion.

Basic Information

Product Name	3-Hydroxy Repaglinide
CAS No.	121167-81-5
Molecular Formula	C27H36N2O4
Molecular Weight	452.59 g/mol
Synonyms	3-Hydroxyrepaglinide; Repaglinide Impurity C; Repaglinide Metabolite; 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic Acid; AG-EE 623 ZW; S-2168; (S)-2-Ethoxy-4-[2-[(3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl)amino]-2-oxoethyl]benzoic Acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Repaglinide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to meet the stringent requirements for pharmaceutical reference standards and intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.