Description

Big Et-1 (1-38) (Human) is a synthetic peptide fragment corresponding to a specific region of the human endothelin-1 protein. This compound is a critical research tool for investigating the structure, function, and signaling pathways of endothelin, a potent vasoconstrictor involved in cardiovascular regulation. It is primarily utilized by researchers and developers in the life sciences sector, particularly in cardiovascular disease research, drug discovery, and biochemical assay development. The product is supplied with the CAS registry number 121014-53-7.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of endothelin receptor binding and activation mechanisms.
• Drug Discovery & Development: Serves as a key intermediate or target molecule in screening for endothelin receptor antagonists and modulators.
• Assay Development: Employed in the development and validation of ELISA, RIA, and other immunoassays for detecting endothelin-related biomarkers.
• Cardiovascular Research: Fundamental for in vitro and ex vivo studies modeling vascular contraction, hypertension, and related pathologies.
• Academic & Pharmaceutical R&D: Essential reagent for universities, research institutes, and biopharmaceutical companies focused on peptide biology and cardiovascular therapeutics.

Basic Information

Product Name	Big Et-1 (1-38) (Human)
CAS No.	121014-53-7
Molecular Formula	C187H277N51O57S5
Molecular Weight	4264.9 g/mol
Synonyms	Endothelin-1 (1-38), human; Big Endothelin-1 (1-38); ET-1 (1-38); Big ET-1; Proendothelin-1 (1-38); hET-1(1-38); Preproendothelin-1 fragment (1-38); Big endothelin-1 precursor (1-38)
EINECS	Contact for details

Quality Control

Our Big Et-1 (1-38) (Human) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.