Description

Sarafotoxin S6B is a potent and selective endothelin receptor agonist, a synthetic analog of the natural sarafotoxin peptides. This high-purity compound is critical for advanced pharmacological research, particularly in studying cardiovascular physiology and endothelin receptor signaling pathways. It is an essential tool for researchers and pharmaceutical developers in the fields of cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Pharmacological Research: Used as a selective agonist for endothelin B (ETB) receptors to study receptor function and signaling cascades.
• Cardiovascular Studies: A key tool in investigating vasoconstriction, blood pressure regulation, and the pathophysiology of conditions like pulmonary hypertension.
• Drug Discovery & Screening: Serves as a reference standard and active agent in high-throughput screening (HTS) assays for identifying novel endothelin receptor antagonists.
• Biochemical Assays: Employed in in vitro cell-based assays and tissue bath experiments to characterize receptor-ligand interactions and cellular responses.
• Academic & Institutional Research: Supports basic science research in university and institutional laboratories focused on peptide hormones and G-protein coupled receptors (GPCRs).

Basic Information

Product Name	Sarafotoxin S6B
CAS No.	120972-53-4
Molecular Formula	C115H168N30O33S5
Molecular Weight	2595.1 g/mol
Synonyms	Sarafotoxin S6b; Sarafotoxin S6b Peptide; SRTX-S6B; S6B Sarafotoxin; Endothelin-like peptide; Sarafotoxin b; Sarafotoxin S6b (SRTX-S6B); Sarafotoxin S6B acetate
EINECS	Contact for details

Quality Control

Every batch of Sarafotoxin S6B is manufactured and tested under strict quality management systems to ensure the highest standards of purity and biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, identity, and peptide content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Biological Activity	Assayed; data on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.