Description

Hiv Protease Substrate Ii CAS NO 120944-74-3 is a specialized synthetic peptide substrate designed for the biochemical study and inhibition of the HIV-1 protease enzyme. This compound is a critical tool for pharmaceutical research and development, enabling the screening and characterization of potential antiretroviral drugs. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in antiviral drug discovery and enzymatic assay development.

Application

• HIV Protease Activity Assays: Used as a specific chromogenic or fluorogenic substrate to measure the enzymatic activity of HIV-1 protease in vitro.
• Drug Discovery Screening: Essential for high-throughput screening (HTS) platforms to identify and evaluate novel protease inhibitor candidates.
• Enzyme Kinetic Studies: Employed to determine kinetic parameters (Km, Vmax, kcat) of HIV protease for fundamental biochemical research.
• Diagnostic Development: Serves as a key component in the development of diagnostic tests and kits for monitoring protease function.
• Mechanism of Action Studies: Facilitates research into the cleavage specificity and inhibition mechanisms of HIV protease.
• Quality Control for Inhibitors: Used in the quality control testing of manufactured protease inhibitor drugs to ensure potency and consistency.

Basic Information

Product Name	Hiv Protease Substrate Ii
CAS No.	120944-74-3
Molecular Formula	C45H62N8O11
Molecular Weight	891.03 g/mol
Synonyms	HIV Protease Substrate II; HIV-1 Protease Substrate II; Acetyl-Thr-Ile-Nle-r-Nle-Gln-Arg-NH2; Ac-T-I-Nle-r-Nle-Q-R-NH2; Ac-Thr-Ile-Nle-ψ[CH2NH]-Nle-Gln-Arg-NH2; Reduced Peptide Bond Inhibitor Substrate; HIV PR Substrate II; Protease Inhibitor Screening Substrate
EINECS	Contact for details

Quality Control

Our Hiv Protease Substrate Ii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with research and diagnostic-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on dry basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.