Description

Big Et-1 (1-38) (Human) is a synthetic peptide fragment derived from the human endothelin-1 sequence. This high-purity biochemical is critical for advanced research into vascular biology and cellular signaling pathways. It serves as an essential reference standard and active ingredient for scientists in pharmaceutical R&D, biotechnology, and academic institutions focused on cardiovascular and endothelial function studies.

Application

• Biomedical Research: Used as a precise tool for studying endothelin receptor binding, signal transduction mechanisms, and vascular tone regulation in in vitro and ex vivo assays.
• Pharmaceutical Development: Serves as a key reference standard and pharmacological agent in the screening and development of novel therapeutics targeting endothelin pathways.
• Diagnostic Reagent Manufacturing: Employed in the production and calibration of immunoassay kits and other diagnostic tools for measuring endothelin-related biomarkers.
• Cell Culture & Physiology Studies: Applied in controlled experiments to investigate the effects of endothelin on cell proliferation, differentiation, and physiological responses.
• Academic & Institutional Research: Provides a reliable, high-quality reagent for universities and research institutes conducting fundamental studies in cardiology, nephrology, and endocrinology.

Basic Information

Product Name	Big Et-1 (1-38) (Human)
CAS No.	120796-97-6
Molecular Formula	C187H277N51O55S5
Molecular Weight	4286.9 g/mol
Synonyms	Endothelin-1 (1-38), human; Big Endothelin-1 (1-38); ET-1 (1-38); Big ET-1; Proendothelin-1 (1-38); hET-1(1-38); [Cys1,3,11,15, Ala7]-Endothelin-1 (1-38) (human); Big Endothelin (human).
EINECS	Contact for details

Quality Control

Our Big Et-1 (1-38) (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.