Description

n-Boc-1-Aminocyclobutanecarboxylic Acid is a protected amino acid derivative featuring a cyclobutane ring, a key structural motif in medicinal chemistry. This compound serves as a crucial versatile building block for the synthesis of conformationally constrained peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for creating novel bioactive molecules targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Design: Used to introduce the rigid cyclobutane scaffold into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a component in the linker or warhead sections of bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating constrained amino acid analogs.
• Agrochemical Research: Used as a building block in the development of novel pesticides and herbicides with improved properties.
• Material Science: Potential monomer for creating specialized polymers with unique thermal and mechanical characteristics.

Basic Information

Product Name	n-Boc-1-Aminocyclobutanecarboxylic Acid
CAS No.	120728-10-1
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic Acid; (1-Aminocyclobutyl)carbamic Acid tert-Butyl Ester; Boc-ACBC-OH; Boc-1-Amino-cyclobutanecarboxylic Acid; tert-Butyl (1-aminocyclobutyl)carbamate; Cyclobutaneglycine, 1-(N-Boc-amino)-; N-Boc-1-Aminocyclobutanecarboxylic Acid; 1-N-Boc-aminocyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-1-Aminocyclobutanecarboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.