Description

Defensin HNP-2 (Human) is a cationic antimicrobial peptide belonging to the α-defensin family, a critical component of the innate immune system. This peptide is of significant interest for its potent, broad-spectrum activity against bacteria, fungi, and enveloped viruses. It is primarily utilized in advanced biomedical research and therapeutic development. Key industries requiring this high-purity biochemical include pharmaceutical R&D, immunology studies, and the development of novel anti-infective agents.

Application

• Immunology and Innate Immunity Research: Fundamental studies on neutrophil function, peptide-mediated host defense mechanisms, and inflammation.
• Antimicrobial Agent Development: Serves as a lead compound or model for designing new synthetic peptides or peptidomimetics with enhanced stability and activity.
• Biomaterial and Medical Device Coatings: Investigation into coating surfaces to prevent bacterial colonization and biofilm formation.
• Cancer Research: Exploration of defensins' cytotoxic effects on certain tumor cell lines and their role in the tumor microenvironment.
• Diagnostic Assay Development: Used as a standard or reagent in ELISA and other immunoassays to detect defensin levels in clinical samples.
• Pharmaceutical Excipient Research: Studying its potential as a permeation enhancer or stabilizing agent in drug formulation.

Basic Information

Product Name	Defensin HNP-2 (Human)
CAS No.	120721-97-3
Molecular Formula	C206H339N65O53S6
Molecular Weight	~ 3372.8 g/mol
Synonyms	Human Neutrophil Peptide-2; HNP-2; Defensin, alpha 1; HP-2; NP-2; DEFA1; Neutrophil Defensin 2; Antimicrobial Peptide HNP-2; α-Defensin 1
EINECS	Contact for details

Quality Control

Our Defensin HNP-2 (Human) is produced and tested to meet stringent quality standards suitable for research applications. Each batch is characterized to ensure identity, purity, and biological activity. Certificates of Analysis (COA) detailing purity by HPLC, peptide content, mass spectrometry (MS) confirmation, and endotoxin levels are provided to guarantee batch-to-batch consistency and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. Aliquotting is recommended for repeated use to avoid freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	3372.8 ± 2 Da (by MS)
Water Content (KF)	≤ 5.0 %
Endotoxin Level	< 10 EU/mg
Biological Activity	Assayed by antimicrobial activity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.