Description

Gadolinium-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetrakis(Methylenephosphonic Acid) CAS NO 120721-77-9 is a highly functionalized macrocyclic chelating agent, specifically designed for the stable complexation of gadolinium (Gd³⁺) ions. This compound is critical for creating advanced contrast agents with superior thermodynamic and kinetic stability, which is paramount for safety and efficacy in high-resolution imaging. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and medical diagnostics sectors for developing next-generation magnetic resonance imaging (MRI) contrast media.

Application

• MRI Contrast Agent Precursor: As the organic ligand for gadolinium in the synthesis of high-relaxivity, macrocyclic-based MRI contrast agents (e.g., analogs of Gadoteric acid).
• Biomedical Research: Used in developing targeted imaging probes for research in oncology, cardiovascular disease, and neurology.
• Radiopharmaceutical Development: Serves as a bifunctional chelator platform for attaching gadolinium to antibodies, peptides, or other targeting molecules for molecular imaging.
• Chemical Synthesis Intermediate: A key building block for chemists synthesizing novel lanthanide complexes with tailored properties.
• Material Science: Potential use in creating gadolinium-doped materials for sensors or optical applications due to its strong chelating properties.

Basic Information

Item	Details
Product Name	Gadolinium-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetrakis(Methylenephosphonic Acid)
CAS No.	120721-77-9
Molecular Formula	C₁₆H₄₀GdN₄O₁₂P₄
Molecular Weight	Contact for details
Synonyms	Gadolinium DOTA-tetrakis(methylenephosphonate); Gd-DOTP; Gadolinium(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakis(phosphonate); Gd-DOTP⁵⁻; Gadolinium complex of DOTP; Tetraazacyclododecane tetramethylene phosphonate gadolinium chelate; DOTP-Gd; HOPO-based Gd chelator (related class)
EINECS	Contact for details

Quality Control

Our Gadolinium-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-Tetrakis(Methylenephosphonic Acid) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting key parameters such as assay, impurity profile, and residual solvent content are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Gadolinium Content	Contact for details
Free Gadolinium	≤ 0.1%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%
pH (1% Solution)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.