Description

Gadolinium 1,5,9-Triazacyclododecane-N,N',N''-Tris(Methylenephosphonic Acid) is a highly specialized macrocyclic chelating agent, valued for its exceptional ability to form stable, high-relaxivity complexes with gadolinium(III) ions. This property is critical for enhancing contrast in magnetic resonance imaging (MRI), making it a key intermediate in the development of advanced diagnostic agents. It is primarily required by pharmaceutical R&D laboratories, contrast media manufacturers, and advanced materials researchers working on next-generation imaging technologies.

Application

• MRI Contrast Agent Precursor: Serves as a critical building block for synthesizing high-relaxivity, macrocyclic gadolinium-based contrast agents (GBCAs) with improved kinetic stability.
• Pharmaceutical Research & Development: Used in the discovery and development of novel diagnostic imaging compounds for enhanced tissue specificity and safety profiles.
• Bioconjugation Chemistry: Acts as a versatile platform for attaching targeting vectors (e.g., peptides, antibodies) to create targeted MRI probes for molecular imaging.
• Material Science: Employed in the synthesis of functionalized nanomaterials and metal-organic frameworks (MOFs) for sensing and catalytic applications.
• Radiopharmaceuticals: Investigated as a potential chelator for other lanthanide radionuclides used in positron emission tomography (PET) or therapy.
• Academic & Industrial Research: Utilized in studies of lanthanide coordination chemistry, relaxivity mechanisms, and the design of new multimodal imaging agents.

Basic Information

Product Name	Gadolinium 1,5,9-Triazacyclododecane-N,N',N''-Tris(Methylenephosphonic Acid)
CAS No.	120691-20-5
Molecular Formula	C15H30GdN3O9P3
Molecular Weight	Approx. 658.61 g/mol
Synonyms	Gadolinium(III) 1,5,9-triazacyclododecane-1,5,9-triyl-tris(methylenephosphonate); Gd(DOTP); Gadolinium-DOTP; Gd-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylenephosphonic Acid) (common mis-assignment); Gadolinium complex of DOTP; DOTP-Gd; 1,5,9-Triazacyclododecane-N,N',N''-tris(methylenephosphonic acid) gadolinium complex
EINECS	Contact for details

Quality Control

Our Gadolinium 1,5,9-Triazacyclododecane-N,N',N''-Tris(Methylenephosphonic Acid) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as Gadolinium content, purity by HPLC, and free ligand content are provided and available upon request. We support development projects requiring material produced under cGMP guidelines for preclinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., argon or nitrogen) for long-term storage to prevent degradation. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Gadolinium (Gd) Content	22.0 - 24.5 %
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.