Description

Mu-Agatoxin I is a potent and highly selective peptide neurotoxin originally isolated from the venom of the funnel-web spider, *Agelenopsis aperta*. This compound is a crucial pharmacological tool for the study of P/Q-type voltage-gated calcium channels (Cav2.1), which play a vital role in neurotransmitter release and neuronal excitability. It is primarily utilized by neuroscience researchers, pharmaceutical discovery teams, and diagnostic developers for channel characterization, assay development, and the investigation of neurological disorders.

Application

• Neuroscience Research: Selective blockade of P/Q-type calcium channels (Cav2.1) in electrophysiology and cellular signaling studies.
• Pharmacological Tool: Used as a reference standard and selective inhibitor in high-throughput screening (HTS) assays for drug discovery targeting calcium channels.
• Mechanistic Studies: Investigation of synaptic transmission, neurotransmitter release mechanisms, and neuronal circuit function.
• Disease Model Research: Tool for studying pathologies linked to Cav2.1 dysfunction, such as migraine, ataxia, and epilepsy.
• Diagnostic Development: Potential use in the development of assays for channelopathy detection and biomarker research.
• Biochemical Reagent: Component in kits and buffers for isolating or studying specific neuronal cell populations and calcium channel subtypes.

Basic Information

Product Name	Mu-Agatoxin I
CAS No.	120500-28-9
Molecular Formula	C184H281N55O53S7
Molecular Weight	~4280.9 g/mol
Synonyms	ω-Agatoxin IA; Mu-Aga-I; ω-Aga-IA; P/Q-type calcium channel blocker; Calcium channel toxin ω-Agatoxin IA; Agatoxin, ω-Aga-IA; Spider toxin ω-Agatoxin IA; Voltage-gated calcium channel inhibitor ω-Agatoxin IA
EINECS	Contact for details

Quality Control

Our Mu-Agatoxin I is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC, mass spectrometry (MS) for identity confirmation, and functional activity testing in standardized bioassays. A detailed Certificate of Analysis (COA), providing full specifications and test results, is supplied with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically low nM range for P/Q-type channels)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers (e.g., PBS, saline) or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.