Description

1,2,4-Oxadiazole-3-Carboximidamide,n-Hydroxy-5-(Trifluoromethyl)-(9Ci) is a high-value, functionalized heterocyclic building block characterized by its trifluoromethyl and hydroxyamidine substituents. This compound is essential for medicinal chemistry and agrochemical research, serving as a key precursor for synthesizing novel molecules with enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, crop protection, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A critical synthon for developing new active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological efficacy.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme mechanisms and protein-ligand interactions.
• Material Science Precursor: Potential use in synthesizing specialty polymers and ligands for catalysts or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library generation.

Basic Information

Product Name	1,2,4-Oxadiazole-3-Carboximidamide,n-Hydroxy-5-(Trifluoromethyl)-(9Ci)
CAS No.	120493-20-1
Molecular Formula	C4H3F3N4O
Molecular Weight	180.09 g/mol
Synonyms	5-(Trifluoromethyl)-1,2,4-oxadiazole-3-carboximidamide, N-hydroxy-; 3-Carbamimidoyl-5-(trifluoromethyl)-1,2,4-oxadiazol-3-ium-3-olate; N-Hydroxy-5-(trifluoromethyl)-1,2,4-oxadiazole-3-carboximidamide; 5-(Trifluoromethyl)-1,2,4-oxadiazole-3-carboximidamide N-oxide; 120493-20-1; 3-(N-Hydroxyamidino)-5-(trifluoromethyl)-1,2,4-oxadiazole
EINECS	Contact for details

Quality Control

Our 1,2,4-Oxadiazole-3-Carboximidamide,n-Hydroxy-5-(Trifluoromethyl)-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Standard Grade)
Purity (HPLC)	≥ 98% (High Purity Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.