Description

2-(N'-Acetylphenylalanyl)Hydroxyethyl 2'-Pyridyl Disulfide is a specialized, heterobifunctional crosslinking agent featuring a reactive disulfide bond and an activated ester group. This compound is critical for creating reversible, cleavable linkages in bioconjugation strategies, enabling advanced research in protein chemistry and drug delivery systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing targeted therapeutics and sophisticated diagnostic tools.

Application

• Bioconjugation Reagent: For the site-specific modification of proteins, peptides, and antibodies to create cleavable drug conjugates.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and the study of protein-protein interactions via disulfide exchange.
• Drug Delivery Systems: Facilitates the development of stimuli-responsive nanocarriers where the disulfide bond is cleaved in the reductive intracellular environment.
• Surface Immobilization: Enables the controlled attachment of biomolecules to gold surfaces or other materials for biosensor development.
• Crosslinking Agent: For the synthesis of smart hydrogels and polymeric materials with redox-sensitive properties.
• Intermediate in Organic Synthesis: Serves as a key building block for synthesizing more complex molecules with tailored reactivity.

Basic Information

Product Name	2-(N'-Acetylphenylalanyl)Hydroxyethyl 2'-Pyridyl Disulfide
CAS No.	120484-56-2
Molecular Formula	C₁₈H₂₀N₂O₄S₂
Molecular Weight	392.49 g/mol
Synonyms	N-Acetyl-L-phenylalanyl-N-(2-hydroxyethyl)-2-pyridyldisulfide; 2-(N-Acetylphenylalanyl)hydroxyethyl 2-pyridyl disulfide; 2-(N-Acetyl-L-phenylalanyl)hydroxyethyl 2-pyridyl disulfide; SPDP derivative; Heterobifunctional crosslinker; Ac-Phe-HEPDS; 2-Pyridyldisulfide derivative of N-acetylphenylalanine hydroxethyl ester
EINECS	Contact for details

Quality Control

Our 2-(N'-Acetylphenylalanyl)Hydroxyethyl 2'-Pyridyl Disulfide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our global customer base in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.