Description

n-(2-Amino-2-Oxoethyl)-n-[(1S)-2-(3,5-Dioxo-1-Piperazinyl)-1-Methylethyl]-Glycine is a specialized, high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex molecular architecture, featuring both amino acid and piperazine-dione moieties, makes it a valuable building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in areas requiring sophisticated peptide-mimetic or heterocyclic structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially protease inhibitors and other enzyme-targeted molecules.
• Peptidomimetic Research: Serves as a crucial scaffold for designing and constructing peptide analogs with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Used in the development of specialized probes and ligands for studying enzyme-substrate interactions and signal transduction pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of investigational new drugs (INDs).
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in medicinal chemistry and organic synthesis.

Basic Information

Product Name	n-(2-Amino-2-Oxoethyl)-n-[(1S)-2-(3,5-Dioxo-1-Piperazinyl)-1-Methylethyl]-Glycine
CAS No.	120418-77-1
Molecular Formula	C11H18N4O6
Molecular Weight	302.29 g/mol
Synonyms	Glycine, N-(2-amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-; (S)-2-(2-(2-Aminoacetamido)propanamido)acetic acid; 2,5-Dioxopiperazine-1-acetamide derivative; L-Configuration amino acid intermediate; Chiral piperazinedione-glycine hybrid; Pharmaceutical intermediate 120418-77-1; Research chemical CAS 120418-77-1
EINECS	Contact for details

Quality Control

We supply this advanced intermediate under strict quality protocols suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical methods including HPLC, NMR, and mass spectrometry. Our quality system supports traceability and data integrity, meeting the expectations of global pharmaceutical and research partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.