Description

Perindopril Acyl-B-D-Glucuronide is a major inactive metabolite of the angiotensin-converting enzyme (ACE) inhibitor, Perindopril. This compound is of significant importance in the field of pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a critical reference standard for analytical laboratories and drug manufacturers. Professionals in pharmaceutical R&D, bioanalytical testing, and regulatory compliance require this high-purity metabolite to ensure accurate drug monitoring and safety assessments.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Perindopril and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the metabolic pathways, clearance rates, and bioavailability of Perindopril.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, or LC-MS/MS methods for clinical and preclinical studies.
• Impurity Profiling: Acts as a known impurity or degradation product standard for the quality control of Perindopril active pharmaceutical ingredient (API) and finished dosage forms.
• Regulatory Submissions: Supports investigational new drug (IND) and new drug application (NDA) filings by providing definitive metabolite identification data.
• Toxicology Studies: Employed in safety assessments to understand the exposure and potential effects of Perindopril metabolites.

Basic Information

Product Name	Perindopril Acyl-B-D-Glucuronide
CAS No.	120398-66-5
Molecular Formula	C27H41N3O11
Molecular Weight	583.63 g/mol
Synonyms	Perindopril Acyl Glucuronide; Perindopril Glucuronide; (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid β-D-Glucopyranosiduronic acid; Perindopril Metabolite; Perindopril Acyl-β-D-Glucuronide; Glucuronide conjugate of Perindopril
EINECS	Contact for details

Quality Control

Our Perindopril Acyl-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the container to reach room temperature before opening to minimize moisture condensation. The material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.