Description

α-[(2-Nitro-1H-Imidazole-1-Yl)Methyl]-6-Azabicyclo[3.1.0]Hexane-6-Ethanol is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic structure fused with a nitroimidazole moiety. This compound matters for its critical role as a key building block in the synthesis of novel, potent therapeutic agents, particularly in oncology and anti-infective research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material to develop next-generation drug candidates, where its precise chemical architecture enables targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Oncology Research: Used in the development of experimental chemotherapeutic and radiosensitizing agents due to the bioreductive properties of the nitroimidazole group.
• Anti-infective Drug Development: Applied in research for creating new antimicrobial and antiparasitic compounds.
• Bioconjugation & Prodrug Synthesis: The ethanol functional group allows for conjugation chemistry, enabling the creation of targeted drug delivery systems.
• Chemical Biology & Proteomics: Utilized as a molecular probe or tag in studies investigating enzyme function and cellular pathways.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	α-[(2-Nitro-1H-Imidazole-1-Yl)Methyl]-6-Azabicyclo[3.1.0]Hexane-6-Ethanol
CAS No.	120277-93-2
Molecular Formula	C11H16N4O3
Molecular Weight	252.27 g/mol
Synonyms	6-Azabicyclo[3.1.0]hexane-6-ethanol, α-[(2-nitro-1H-imidazol-1-yl)methyl]-; 1-[(6-Azabicyclo[3.1.0]hex-6-yl)methyl]-2-nitro-1H-imidazole-1-ethanol; 2-Nitro-1-[(6-azabicyclo[3.1.0]hex-6-yl)methyl]-1H-imidazole-1-ethanol; ABH-Nitroimidazole Derivative; Nitroimidazole Bicyclic Intermediate
EINECS	Contact for details

Quality Control

Our α-[(2-Nitro-1H-Imidazole-1-Yl)Methyl]-6-Azabicyclo[3.1.0]Hexane-6-Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.