Description

(R)-(-)-Mosapramine CAS NO 120181-35-3 is the single enantiomer of the atypical antipsychotic agent Mosapramine, representing a high-purity chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters as it enables the study of stereospecific biological activity, which is critical for developing more potent and selective therapeutics with potentially reduced side-effect profiles. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical suppliers focused on neuropharmacology, specifically for the development and synthesis of next-generation central nervous system (CNS) drugs.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in API manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral synthon in the research-scale synthesis of enantiomerically pure Mosapramine and its derivatives.
• Mechanistic & Pharmacological Studies: Used in vitro and in vivo to investigate the stereoselective binding and efficacy of dopaminergic and serotonergic receptor modulation.
• Process Chemistry & Route Scouting: Employed in the development and optimization of asymmetric synthetic pathways for complex chiral molecules.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying the undesired (S)-(+)-enantiomer in racemic Mosapramine batches.

Basic Information

Product Name	(R)-(-)-Mosapramine
CAS No.	120181-35-3
Molecular Formula	C₂₄H₃₀ClN₃O₂
Molecular Weight	427.97 g/mol
Synonyms	(R)-Mosapramine; (-)-Mosapramine; (R)-(-)-Cremin; Y-516; (3R)-3-[3-(4-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)propyl]-1-methylpiperidine-4-spiro-5'-imidazolidine-2',4'-dione; (R)-3-[3-(4-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)propyl]-1-methyl-4-spiro(2',4'-dioxoimidazolidin-5')piperidine
EINECS	Contact for details

Quality Control

Our (R)-(-)-Mosapramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting research-grade specifications. A detailed Certificate of Analysis (COA) providing identity, purity (typically ≥98%), enantiomeric excess (ee), and impurity profile is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.