Description

n-Boc-2-(4-Bromo-Phenyl)-Ethylamine is a protected amine derivative, specifically a tert-butyloxycarbonyl (Boc)-protected phenethylamine bearing a bromo substituent, serving as a crucial synthetic intermediate in advanced organic synthesis. This compound matters because it provides a versatile and reactive handle for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where the bromine atom and protected amine group are key for subsequent coupling and functionalization reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in the development of central nervous system (CNS) agents, kinase inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the bromophenyl moiety is incorporated into active structures.
• Peptidomimetics & Bioconjugation: Serves as a precursor for non-natural amino acids or as a linker in the construction of peptide mimetics and bioconjugates.
• Material Science Research: Employed as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Heck, or Buchwald-Hartwig amination.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	n-Boc-2-(4-Bromo-Phenyl)-Ethylamine
CAS No.	120157-97-3
Molecular Formula	C₁₃H₁₈BrNO₂
Molecular Weight	300.19 g/mol
Synonyms	1-Boc-2-(4-Bromophenyl)ethylamine; 2-(4-Bromophenyl)ethanamine, N-Boc-protected; tert-Butyl [2-(4-bromophenyl)ethyl]carbamate; N-(tert-Butoxycarbonyl)-2-(4-bromophenyl)ethylamine; 4-Bromo-N-Boc-phenethylamine; N-Boc-4-bromophenethylamine; Boc-4-Br-Phe-NH2 (abbrev.); 2-(4-Bromophenyl)ethylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-2-(4-Bromo-Phenyl)-Ethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.