Description

2-Chloro-4-Ethynyl-1-Methoxybenzene is a specialized aromatic building block featuring both chloro and ethynyl functional groups on a methoxybenzene scaffold. This unique structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients and by material scientists exploring new polymers and electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in creating tagged molecules or probes for studying biological pathways and protein interactions via click chemistry.
• Organic Synthesis: A versatile reagent for cross-coupling reactions (e.g., Sonogashira, Suzuki) to create complex, functionalized aromatic systems.

Basic Information

Product Name	2-Chloro-4-Ethynyl-1-Methoxybenzene
CAS No.	120136-29-0
Molecular Formula	C9H7ClO
Molecular Weight	166.60 g/mol
Synonyms	1-Chloro-2-methoxy-4-ethynylbenzene; 4-Ethynyl-2-chloroanisole; 2-Chloro-4-ethynylanisole; 2-Chloro-1-methoxy-4-ethynylbenzene; 4-Ethynyl-2-chloro-1-methoxybenzene; 2-Chloro-4-ethynylmethoxybenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Ethynyl-1-Methoxybenzene is produced and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR, and GC-MS to ensure identity and consistency. A Certificate of Analysis (COA) is available for each lot, and we support custom purity requirements for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.