Description

4-Ethynyl-2-Fluoro-1-Methoxy-Benzene is a high-purity fluorinated aromatic building block featuring an ethynyl functional group. This compound is critical for advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector to construct novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, especially in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides with enhanced activity.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic frameworks.
• Ligand & Catalyst Development: The ethynyl group enables its use in creating novel ligands for catalytic systems and metal-organic complexes.
• Fluorescent Probe & Dye Synthesis: Acts as a building block for synthesizing fluorophores and molecular probes used in bio-imaging and diagnostics.
• Academic & Contract Research: Essential for exploratory chemistry in academic institutions and CROs (Contract Research Organizations).

Basic Information

Product Name	4-Ethynyl-2-Fluoro-1-Methoxy-Benzene
CAS No.	120136-28-9
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	2-Fluoro-4-ethynylanisole; 1-Ethynyl-4-fluoro-2-methoxybenzene; 4-Ethynyl-2-fluoroanisole; 2-Fluoro-4-ethynyl-1-methoxybenzene; 1-Methoxy-2-fluoro-4-ethynylbenzene; 4-Ethynyl-2-fluoromethoxybenzene; 2-Fluoro-4-(ethynyl)anisole
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2-Fluoro-1-Methoxy-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from strong acids and incompatible organic solvents. Due to its sensitivity, the container should be kept sealed and allowed to reach ambient temperature before opening to minimize moisture ingress and oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.