Description

n-tert-Butyloxycarbonyl Glutathione Dimethyl Diester is a protected derivative of the essential tripeptide glutathione, featuring tert-butoxycarbonyl (Boc) and methyl ester protecting groups. This chemical modification is crucial for synthetic organic and peptide chemistry, providing stability and enabling selective deprotection strategies. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of prodrugs, enzyme inhibitors, and advanced biochemical probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate protected glutathione motifs into larger peptide sequences.
• Biochemical Research: Serves as a precursor in studies of glutathione metabolism, oxidative stress pathways, and redox biology.
• Prodrug Development: Utilized in designing prodrugs that leverage glutathione's role in cellular detoxification for targeted drug delivery.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Enzyme Inhibitor Synthesis: Intermediate for creating compounds that modulate the activity of glutathione-S-transferases and related enzymes.

Basic Information

Product Name	n-tert-Butyloxycarbonyl Glutathione Dimethyl Diester
CAS No.	120033-58-1
Molecular Formula	C20H34N4O9S
Molecular Weight	506.57 g/mol
Synonyms	Boc-Glutathione Dimethyl Ester; Boc-GSH(OMe)2; N-Boc-L-glutathione dimethyl ester; γ-L-Glutamyl-L-cysteinylglycine N-Boc dimethyl ester; Glutathione, N-(tert-butoxycarbonyl)-, dimethyl ester; L-Glutathione, N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester; (2S)-2-[(tert-Butoxycarbonyl)amino]-5-[[(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid dimethyl ester
EINECS	Contact for details

Quality Control

Our n-tert-Butyloxycarbonyl Glutathione Dimethyl Diester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.