Description

Rac (Cis/Trans) Donepezil n-Oxide is a key chemical intermediate and reference standard in advanced pharmaceutical research and development. This compound is of significant importance for the study of metabolic pathways and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and quality control of neurological therapeutics, particularly those related to acetylcholinesterase inhibition.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control testing of Donepezil and related compounds.
• Metabolic Studies: Serves as a critical intermediate or marker in pharmacokinetic and drug metabolism research to understand the biotransformation of Donepezil.
• Process Chemistry & Impurity Synthesis: Employed in the development and scaling of synthetic routes for Donepezil, and for the preparation of specified impurities for qualification studies.
• Active Pharmaceutical Ingredient (API) Development: Acts as a building block or precursor in the research and synthesis of new chemical entities targeting neurological disorders.
• Analytical Research: Utilized in academic and industrial laboratories for chromatographic (HPLC, LC-MS) and spectroscopic analysis to identify and quantify related substances.

Basic Information

Product Name	Rac (Cis/Trans) Donepezil n-Oxide
CAS No.	120013-84-5
Molecular Formula	C24H29NO4
Molecular Weight	395.50 g/mol
Synonyms	Donepezil N-Oxide (Racemic); (±)-Donepezil N-Oxide; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine N-Oxide; E2020 N-Oxide; Aricept Impurity (N-Oxide); Rac-Donepezil N-Oxide; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1H-inden-1-one 4-Oxide
EINECS	Contact for details

Quality Control

Our Rac (Cis/Trans) Donepezil n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.