Description

5-o-Desmethyl Donepezil is a key pharmaceutical intermediate and metabolite of the acetylcholinesterase inhibitor Donepezil. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on neuroscience and the development of treatments for cognitive disorders.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of Donepezil and its analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in bioanalytical studies for pharmacokinetic and pharmacodynamic profiling.
• Drug Metabolism Research: Essential for in vitro and in vivo studies to understand the metabolic pathways of Donepezil.
• Analytical Standard: Serves as a high-purity standard for HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Neuroscience Research: Employed in academic and industrial research targeting acetylcholinesterase and related neurological mechanisms.
• Impurity Profiling: Used to identify, quantify, and control related substance impurities in Donepezil drug substance and finished dosage forms.

Basic Information

Product Name	5-o-Desmethyl Donepezil
CAS No.	120013-57-2
Molecular Formula	C23H27NO3
Molecular Weight	365.47 g/mol
Synonyms	5-O-Desmethyl Donepezil; Donepezil Metabolite O-Desmethyl; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine, 5-O-Demethylated; AR-R 15896AR; AR-R15896AR; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1H-inden-1-one, 5-O-Demethyl Derivative; 5-Desmethyl Donepezil
EINECS	Contact for details

Quality Control

Our 5-o-Desmethyl Donepezil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.