Description

6-o-Desmethyl Donepezil is a key pharmaceutical intermediate and metabolite of the acetylcholinesterase inhibitor Donepezil. This compound is of significant value in the research and development of treatments for neurodegenerative disorders, particularly Alzheimer's disease. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories for use in drug metabolism studies, impurity profiling, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of Donepezil and its structural analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) for pharmacokinetic and drug metabolism studies.
• Impurity Standard: Essential for analytical method development and validation to control the quality of Donepezil API (Active Pharmaceutical Ingredient).
• Biochemical Research: Employed in neuroscience research to study acetylcholinesterase inhibition mechanisms and metabolic pathways.
• Process Development: Used in the optimization and scaling of pharmaceutical manufacturing processes.
• Regulatory Compliance: Supports regulatory filings (e.g., with FDA, EMA) by providing necessary impurity and degradation product data.

Basic Information

Product Name	6-o-Desmethyl Donepezil
CAS No.	120013-56-1
Molecular Formula	C23H27NO3
Molecular Weight	365.47 g/mol
Synonyms	6-O-Desmethyl Donepezil; Donepezil Impurity C; Donepezil Related Compound C; 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1H-inden-1-one; AR-R 15896AR; Donepezil Metabolite
EINECS	Contact for details

Quality Control

Our 6-o-Desmethyl Donepezil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.