Description

Synuclein CAS NO 119938-65-7 is a protein of significant interest in neurological research and pharmaceutical development. Its primary value lies in its critical role in the study of neurodegenerative diseases, particularly Parkinson's disease and other synucleinopathies. This makes it an essential reagent for research institutions, diagnostic developers, and biopharmaceutical companies focused on neuroscience, biomarker discovery, and therapeutic target validation.

Application

• Neuroscience Research: Fundamental studies on protein aggregation, neuronal function, and disease mechanisms.
• Diagnostic Assay Development: Used as a key antigen and standard in the development of immunoassays (ELISA, Western Blot) for detecting α-synuclein in biological samples.
• Drug Discovery & Screening: Serves as a target protein in high-throughput screening (HTS) platforms to identify potential inhibitors of fibrillization or aggregation.
• Antibody Production & Validation: Critical for immunizing animals to generate monoclonal or polyclonal antibodies and for subsequent antibody characterization.
• Biomarker Studies: Utilized in cerebrospinal fluid (CSF) and blood-based biomarker research for neurodegenerative conditions.
• Structural Biology: Protein crystallization and NMR studies to understand its conformation and interaction with other molecules.

Basic Information

Product Name	Synuclein
CAS No.	119938-65-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Synuclein; α-Synuclein; NACP; Non-Abeta Component of Alzheimer's Disease Amyloid; SNCA; PARK1; PARK4; Synelfin
EINECS	Contact for details

Quality Control

Our Synuclein is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for purity, identity, and aggregation state using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), endotoxin levels, and functional activity is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/μg
Protein Content (BCA)	≥ 90%
Solubility	Soluble in appropriate aqueous buffers
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.