Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-Methyl- CAS NO 119928-85-7 is a functionalized macrocyclic chelating agent, specifically a methyl-substituted derivative of the classic DOTA ligand. This compound is critically important for its enhanced ability to form exceptionally stable complexes with a wide range of metal ions, particularly lanthanides and actinides. It is primarily needed by researchers and manufacturers in the fields of medical imaging, radiopharmaceuticals, and advanced materials science for developing targeted diagnostics and therapeutics.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing stable chelates with radioisotopes like Gadolinium-157, Lutetium-177, or Yttrium-90 for MRI contrast agents and targeted radionuclide therapy.
• Medical Imaging Research: Development of novel contrast agents for Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) due to its high kinetic inertness and thermodynamic stability.
• Catalysis: As a ligand in homogeneous catalysis, where its rigid macrocyclic structure and multiple coordination sites can stabilize transition metal catalysts for organic synthesis.
• Chemical Separation: Utilized in analytical chemistry and hydrometallurgy for the selective extraction and separation of specific metal ions from complex mixtures.
• Material Science: Incorporation into functional materials, such as metal-organic frameworks (MOFs) or luminescent materials, where precise metal coordination is required.
• Bioconjugation Studies: Used to attach metal complexes to biomolecules (antibodies, peptides) for creating targeted diagnostic and therapeutic probes.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-Methyl-
CAS No.	119928-85-7
Molecular Formula	C21H34N4O8
Molecular Weight	470.52 g/mol
Synonyms	2-Methyl-DOTA; 2-Me-DOTA; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-methyl-; 2-Methyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid; (2-Methyl-1,4,7,10-tetraazacyclodododecane-1,4,7,10-tetrayl)tetraacetic acid; Me-DOTA; 2-Methyl-DOTAc; Methyl-substituted DOTA ligand
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, 2-Methyl- adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere or in a desiccator to maintain stability. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.