Description

α-Cgrp (8-37) (Human) is a synthetic peptide fragment corresponding to the 8-37 sequence of the human Calcitonin Gene-Related Peptide (CGRP). This compound serves as a potent and selective antagonist of the CGRP receptor, making it a critical research tool for studying neurogenic inflammation, migraine pathways, and cardiovascular regulation. It is essential for pharmaceutical R&D, academic research, and diagnostic development focused on CGRP-mediated biological processes.

Application

• Neuroscience Research: Used as a specific receptor antagonist to study the role of CGRP in pain signaling, particularly in migraine and cluster headache models.
• Cardiovascular Studies: Employed to investigate CGRP's vasodilatory effects and its implications in blood pressure regulation and vascular diseases.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in the screening and development of new CGRP-targeting therapeutics.
• In Vitro & In Vivo Assays: Utilized in functional cellular assays (e.g., cAMP inhibition) and animal studies to validate antagonist activity and mechanism of action.
• Diagnostic Reagent Manufacturing: Acts as a key component in the production of immunoassay kits and reagents for CGRP pathway analysis.

Basic Information

Product Name	α-Cgrp (8-37) (Human)
CAS No.	119911-68-1
Molecular Formula	C152H246N44O43S2
Molecular Weight	3367.9 g/mol
Synonyms	hCGRP(8-37); Human CGRP-(8-37); Calcitonin Gene-Related Peptide (8-37), human; CGRP 8-37; α-CGRP (8-37); CGRP Antagonist (8-37); [Tyr0]-CGRP(8-37); CGRP receptor antagonist fragment
EINECS	Contact for details

Quality Control

Our α-Cgrp (8-37) (Human) is manufactured under strict quality systems. Each batch is characterized using advanced analytical techniques including HPLC for purity and Mass Spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues, ensuring compliance with research-grade standards. Custom synthesis to specific purity levels (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (K.F.)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.