Description

Parathyroid Hormone-Related Protein(1-74) is a bioactive peptide fragment that plays a critical role in calcium metabolism and bone physiology. This high-purity synthetic peptide is essential for advanced research and development in endocrinology and oncology. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions investigating hypercalcemia of malignancy, bone disorders, and related signaling pathways.

Application

• Biomedical Research: Used as a key reagent in studying the physiological and pathological roles of PTHrP, including its effects on calcium regulation and bone cell activity.
• Assay Development: Serves as a critical standard and calibrant in the development of immunoassays (ELISA, RIA) for the detection and quantification of PTHrP in biological samples.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms and functional assays to identify and characterize potential therapeutic agents targeting the PTH/PTHrP receptor pathway.
• Cell Culture & In Vitro Studies: Applied in cell-based experiments to investigate cellular signaling, gene expression, and proliferation mechanisms mediated by PTHrP in various cancer and bone cell lines.
• Antibody Production: Acts as a high-quality immunogen for generating specific polyclonal and monoclonal antibodies with research and diagnostic applications.
• Reference Material: Provides a well-defined, pure reference standard for quality control in related biopharmaceutical production and analytical method validation.

Basic Information

Product Name	Parathyroid Hormone-Related Protein(1-74)
CAS No.	119883-46-4
Molecular Formula	C390H623N111O114S2
Molecular Weight	Approx. 8600 Da
Synonyms	PTHrP(1-74); Parathyroid Hormone-like Protein (1-74); PTH-Related Peptide (1-74); PTHLH(1-74); Hypercalcemia of Malignancy Factor; Humoral Hypercalcemic Factor; PTHrP 1-74 Fragment; Parathyrin-Related Protein(1-74)
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone-Related Protein(1-74) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including reversed-phase HPLC for purity assessment, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, endotoxin levels, and biological activity are provided to guarantee consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	Within ± 5 Da of theoretical
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg
Biological Activity	Determined by cell-based assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.