Description

Fmoc-L-Arg(Pmc)-Oh is a protected derivative of the amino acid L-Arginine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of complex peptides and proteins in pharmaceutical research and development. It is essential for scientists and manufacturers in the fields of therapeutic peptide production, biochemical research, and proteomics, where high-purity, sequence-specific synthesis is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the sequential assembly of peptide chains on resin.
• Pharmaceutical Intermediates: Used in the research and GMP manufacturing of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Serves as a precursor for introducing arginine residues into modified peptides for diagnostic or targeting applications.
• Biochemical Research: Employed in academic and industrial labs for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of peptide linkers that connect cytotoxic drugs to monoclonal antibodies.
• Combinatorial Chemistry: A vital component in libraries for high-throughput screening to discover new bioactive molecules.

Basic Information

Product Name	Fmoc-L-Arg(Pmc)-Oh
CAS No.	119831-72-0
Molecular Formula	C33H47N5O7S
Molecular Weight	649.83 g/mol
Synonyms	Fmoc-Arg(Pmc)-OH; N-α-Fmoc-N-ω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine; Fmoc-L-arginine(Pmc)-OH; Fmoc-Arg(Pbf)-OH (common alternative for Pmc); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-ω-[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-1-benzopyran-6-yl)sulfonyl]-L-arginine; Fmoc-Arg(Pmc); Fmoc-Arginine(Pmc)-OH; Fmoc-Arg(Pmc)-OH CAS 119831-72-0
EINECS	Contact for details

Quality Control

Our Fmoc-L-Arg(Pmc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	[α]²⁰D: -15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.