Description

Sulfamethoxazole N4-Glucoside is a key metabolite and reference standard of the widely used antibiotic sulfamethoxazole. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical methods. It serves as a critical tool for scientists and quality control professionals in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity reference materials for method validation and regulatory compliance.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the identification and quantification of sulfamethoxazole metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, bioavailability, and excretion profiles of sulfamethoxazole.
• Analytical Method Development & Validation: Used to develop and validate high-performance liquid chromatography (HPLC), LC-MS/MS, and other analytical techniques in quality control laboratories.
• Impurity Profiling: Serves as a known impurity or degradation product standard to ensure the purity and stability of sulfamethoxazole active pharmaceutical ingredients (APIs) and finished drug products.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxicity of sulfamethoxazole metabolites.
• Academic and Clinical Research: Supports fundamental research in microbiology, pharmacology, and clinical studies related to sulfonamide antibiotics.

Basic Information

Product Name	Sulfamethoxazole N4-Glucoside
CAS No.	119691-75-7
Molecular Formula	C17H21N4O8S
Molecular Weight	441.44 g/mol
Synonyms	N4-(β-D-Glucopyranosyl)sulfamethoxazole; Sulfamethoxazole N-Glucuronide (common misnomer for the glucoside); SMZ N4-Glucoside; 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide N4-β-D-glucopyranoside; Sulfamethoxazole β-D-Glucoside; N-Glucosylsulfamethoxazole; Sulfamethoxazole Phase II Metabolite Reference Standard
EINECS	Contact for details

Quality Control

Our Sulfamethoxazole N4-Glucoside is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with the stringent requirements for reference standards used in pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.