Description

Dynorphin A Amide (1-13), Biocytin(13) is a synthetic, biotinylated peptide fragment derived from the endogenous opioid peptide Dynorphin A. This compound is specifically engineered for advanced neuroscience and biochemical research, offering a powerful tool for labeling and visualizing κ-opioid receptors (KOR). It is essential for researchers in pharmaceutical development and neurobiology who require high-affinity, site-specific probes for receptor localization, binding studies, and signal transduction pathway analysis. The CAS number for this compound is 119622-27-4.

Application

• Neuropharmacology Research: As a high-affinity ligand for studying the distribution and function of κ-opioid receptors (KOR) in the central nervous system.
• Receptor Mapping & Visualization: Utilized in immunohistochemistry (IHC) and fluorescence microscopy due to the biocytin tag, enabling precise anatomical localization of KOR.
• Binding Assays & Screening: Serves as a critical standard or tracer in competitive binding assays to evaluate novel analgesic compounds and receptor antagonists.
• Signal Transduction Studies: Used to investigate KOR-mediated intracellular signaling pathways and their role in pain modulation, stress response, and addiction.
• Biochemical Probe Development: Acts as a precursor for creating advanced conjugates with fluorophores or other detection moieties for enhanced assay sensitivity.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring opioid receptor biology and developing non-addictive pain therapeutics.

Basic Information

Product Name	Dynorphin A Amide (1-13), Biocytin(13)
CAS No.	119622-27-4
Molecular Formula	C91H141N27O23S
Molecular Weight	~2008.34 g/mol
Synonyms	Biocytin(13)-Dynorphin A (1-13) amide; [Biocytin13]-Dynorphin A (1-13)-NH2; Dynorphin A (1-13) amide, Biocytin-labeled; Biotinyl-Dynorphin A (1-13)NH2; Kappa opioid receptor ligand, biotinylated; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys(Biotin)-NH2
EINECS	Contact for details

Quality Control

Every batch of Dynorphin A Amide (1-13), Biocytin(13) is manufactured and analyzed under strict quality protocols to ensure the highest standard of purity and biological activity required for critical research. Our quality commitment includes comprehensive analytical testing via HPLC and MS. A detailed Certificate of Analysis (COA), providing full characterization data including purity, molecular weight confirmation, and peptide content, is supplied with each product and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	2008.34 ± 2.0 Da (by MS)
Solubility	Soluble in water, DMSO, acetic acid solutions
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.