Description

2(S)-2-Trifluoromethylpyrrolidine is a high-value, chiral non-racemic building block featuring a pyrrolidine scaffold substituted with a trifluoromethyl group. This compound is critical for introducing the metabolically stable and lipophilic trifluoromethyl moiety into target molecules, significantly altering their physicochemical and biological properties. It is primarily sought after by pharmaceutical and agrochemical R&D organizations for the synthesis of advanced intermediates and active ingredients, particularly in the development of protease inhibitors, receptor modulators, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), especially for neurological and metabolic disease targets.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group enhances bioavailability and environmental stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Peptidomimetics & Bioisosteres: Incorporated into peptide analogs to improve metabolic stability, membrane permeability, and binding affinity.
• Material Science Research: Explored as a component in specialty polymers and advanced organic materials for electronic applications.
• Fluorine Chemistry Research: A valuable reagent for studying the introduction and effects of fluorine atoms in complex molecular architectures.

Basic Information

Product Name	2(S)-2-Trifluoromethylpyrrolidine
CAS No.	119580-41-5
Molecular Formula	C5H8F3N
Molecular Weight	139.12 g/mol
Synonyms	(S)-2-(Trifluoromethyl)pyrrolidine; (S)-2-Trifluoromethylpyrrolidine; (S)-α-(Trifluoromethyl)pyrrolidine; L-2-Trifluoromethylpyrrolidine; (-)-2-Trifluoromethylpyrrolidine; Pyrrolidine, 2-(trifluoromethyl)-, (2S)-; 2-Trifluoromethylpyrrolidine, (S)-
EINECS	Contact for details

Quality Control

Our 2(S)-2-Trifluoromethylpyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.