Description

1-(Difluoromethoxy)-3-(Trifluoromethyl)Benzene is a high-value fluorinated aromatic building block, prized for its unique combination of electron-withdrawing substituents that impart exceptional stability and reactivity. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where the introduction of fluorine atoms is required to modulate biological activity, lipophilicity, and metabolic stability. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy and trifluoromethyl groups enhance product efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal properties, and surface characteristics.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to construct complex, fluorinated molecular architectures.
• Research & Development: Essential for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated arenes.

Basic Information

Product Name	1-(Difluoromethoxy)-3-(Trifluoromethyl)Benzene
CAS No.	119558-79-1
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	3-(Trifluoromethyl)phenyl difluoromethyl ether; α,α-Difluoro-3-(trifluoromethyl)anisole; 3-(Trifluoromethyl)difluoromethoxybenzene; m-(Trifluoromethyl)difluoromethoxybenzene; 1-Difluoromethoxy-3-trifluoromethyl-benzene; Benzene, 1-(difluoromethoxy)-3-(trifluoromethyl)-; DFMTFB
EINECS	Contact for details

Quality Control

Every batch of 1-(Difluoromethoxy)-3-(Trifluoromethyl)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat sources and open flame. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.1%
Density (20°C)	~1.45 g/cm³
Refractive Index (n20D)	~1.40 - 1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.