Description

H-Tle-Otbu Hcl CAS NO 119483-45-3 is a protected amino acid derivative, specifically the hydrochloride salt of N-(tert-Butoxycarbonyl)-L-tert-leucine. This compound is a critical building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), valued for its role in introducing sterically hindered, chiral centers. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for advanced drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and novel therapeutic agents.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate the bulky, hydrophobic tert-leucine residue.
• API Development: Serves as a crucial building block in the research and production of Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Employed in the modification of proteins and other biomolecules for research and diagnostic applications.
• Chemical Biology Research: Utilized in the study of protein-protein interactions and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Acts as a specialized intermediate for creating complex organic molecules with high stereochemical purity.

Basic Information

Product Name	H-Tle-Otbu Hcl
CAS No.	119483-45-3
Molecular Formula	C11H22ClNO4
Molecular Weight	267.75 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-tert-leucine hydrochloride; Boc-L-tert-leucine hydrochloride; Boc-Tle-OH·HCl; (2S)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3,3-dimethylbutanoic acid hydrochloride; (S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric acid hydrochloride; Boc-tert-Leu-OH·HCl; L-tert-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride
EINECS	Contact for details

Quality Control

Our H-Tle-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and GMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a controlled atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.