Description

Nalmafene 3-o-Diglucuronide is a key glucuronide metabolite of the opioid antagonist nalmefene. This compound is of significant value in pharmaceutical research and development, particularly for metabolic profiling and pharmacokinetic studies. It is essential for laboratories and manufacturers focused on drug metabolism, forensic toxicology, and the development of advanced analytical standards. The CAS number for this compound is 119465-20-2.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of nalmefene and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, bioavailability, and excretion profiles of nalmefene in preclinical and clinical research.
• Forensic Toxicology: Employed as an analytical standard in forensic labs for the accurate detection and confirmation of nalmefene use in urine, blood, or other specimens.
• Biomarker Research: Facilitates studies on the correlation between metabolite levels and drug efficacy or safety outcomes.
• Method Development and Validation: Essential for developing, optimizing, and validating sensitive analytical methods such as LC-MS/MS or HPLC in compliance with GLP guidelines.
• Clinical Trial Support: Provides a reliable standard for monitoring metabolite concentrations during clinical trials for opioid dependence treatments.

Basic Information

Product Name	Nalmafene 3-o-Diglucuronide
CAS No.	119465-20-2
Molecular Formula	C36H45NO17
Molecular Weight	739.74 g/mol
Synonyms	Nalmefene 3-O-β-D-diglucuronide; 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol 3-(β-D-Glucopyranosiduronic acid)-(1->2)-β-D-glucopyranosiduronic acid; Nalmefene Diglucuronide; 6-Desoxy-6-methylenenaltrexone Diglucuronide; Nalmafene-3-O-diglucuronide
EINECS	Contact for details

Quality Control

Our Nalmafene 3-o-Diglucuronide is manufactured under strict quality systems suitable for research and analytical applications. Each batch undergoes rigorous identity, purity, and stability testing using advanced chromatographic (HPLC, LC-MS) and spectroscopic (NMR, IR) techniques to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.