Description

Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Nitro- CAS NO 119349-11-0 is a protected amino acid derivative, specifically a Boc-protected nitro-phenylalanine analog, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of the phenylalanine moiety with orthogonal protecting groups, facilitating complex multi-step reactions in peptide and pharmaceutical research. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel peptide-based drugs and bioactive compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues with orthogonal protection (Boc group).
• Research & Development: Serves as a crucial building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• API Manufacturing: Intermediate in the production pathway for complex Active Pharmaceutical Ingredients (APIs) requiring specific amino acid modifications.
• Bioconjugation: Potential use in the preparation of chemically modified peptides for bioconjugation and probe development, leveraging the reactive nitro group for further functionalization.
• Fine Chemical Synthesis: Employed in the asymmetric synthesis of non-natural amino acids and other high-value specialty chemicals.

Basic Information

Product Name	Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Nitro-
CAS No.	119349-11-0
Molecular Formula	C14H18N2O6
Molecular Weight	310.30 g/mol
Synonyms	Boc-3-nitro-L-phenylalanine; N-Boc-3-nitro-L-phenylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(3-nitrophenyl)propanoic acid; tert-Butoxycarbonyl-3-nitro-L-phenylalanine; Boc-Phe(3-NO2)-OH; N-(tert-Butoxycarbonyl)-3-nitro-L-phenylalanine; 3-Nitro-L-phenylalanine N-Boc derivative; BOC-L-PHE(3-NO2)-OH
EINECS	Contact for details

Quality Control

Our Phenylalanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Nitro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.