Description

Boc-D-Penicillamine CAS NO 119222-62-7 is a protected derivative of the non-proteinogenic amino acid D-penicillamine, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly in oncology and autoimmune disease research.
• Peptide Synthesis: Used as a protected amino acid derivative in both solid-phase peptide synthesis (SPPS) and solution-phase methodologies to construct peptide chains with specific stereochemistry.
• Bioconjugation: Employed in the preparation of chemically modified peptides and proteins for antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Research: Acts as a tool compound for studying enzyme mechanisms, metal chelation, and protein folding due to its unique thiol and amine groups (after deprotection).
• Ligand and Catalyst Development: Utilized in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks.

Basic Information

Product Name	Boc-D-Penicillamine
CAS No.	119222-62-7
Molecular Formula	C10H19NO4S
Molecular Weight	249.33 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-mercapto-3-methylbutanoic acid; D-2-Amino-3-mercapto-3-methylbutanoic acid N-Boc derivative; N-(tert-Butoxycarbonyl)-D-penicillamine; Boc-D-Pen-OH; N-Boc-D-penicillamine; Boc-D-β,β-dimethylcysteine; (R)-2-((tert-Butoxycarbonyl)amino)-3-methyl-3-sulfanylbutanoic acid
EINECS	Contact for details

Quality Control

Our Boc-D-Penicillamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to ensure the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.