Description

Parathyroid Hormone (8-84) CAS NO 119144-75-1 is a bioactive fragment of the full-length parathyroid hormone, representing a critical research tool for studying calcium and phosphate metabolism. This high-purity peptide is essential for investigating bone biology, renal function, and endocrine signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on metabolic disorders and osteoporosis research.

Application

• Biomedical Research: Fundamental studies on the structure-activity relationship (SAR) of parathyroid hormone and its receptor interactions.
• Drug Discovery & Development: Serving as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics for osteoporosis and hyperparathyroidism.
• Diagnostic Assay Development: Use as a calibrated antigen or standard in immunoassays (e.g., ELISA) to measure PTH levels in clinical samples.
• Cell Biology & Signaling Studies: Investigating intracellular calcium mobilization and cAMP pathway activation in target cells like osteoblasts and renal tubule cells.
• Quality Control & Validation: Acting as a system suitability standard in analytical laboratories for method development and validation of peptide analysis.

Basic Information

Product Name	Parathyroid Hormone (8-84)
CAS No.	119144-75-1
Molecular Formula	C390H637N115O118S2
Molecular Weight	8785.9 g/mol (theoretical)
Synonyms	PTH (8-84); Parathyroid Hormone Fragment 8-84; Human Parathyroid Hormone (8-84); hPTH (8-84); PTH 8-84; Parathyrin (8-84); CAS 119144-75-1
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (8-84) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.