Description

Ethanone, 1-(1-Fluoro-2-Hydroxycyclohexyl)-, trans- (9Ci) is a specialized fluorinated ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a trans-configured fluorohydrin moiety on a cyclohexyl ring, makes it a valuable chiral intermediate for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries. Its application is critical for the development of novel active ingredients where the introduction of fluorine can dramatically alter biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for introducing fluorinated, stereodefined cyclohexyl motifs.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and target binding.
• Material Science Research: Acts as a precursor for novel fluorinated polymers or liquid crystals with tailored properties.
• Asymmetric Catalysis Studies: Employed as a test substrate or ligand precursor in the development of new catalytic methodologies.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	Ethanone, 1-(1-Fluoro-2-Hydroxycyclohexyl)-, trans- (9Ci)
CAS No.	119030-22-7
Molecular Formula	C8H13FO2
Molecular Weight	160.18 g/mol
Synonyms	trans-1-(1-Fluoro-2-hydroxycyclohexyl)ethanone; 1-Acetyl-1-fluoro-2-hydroxycyclohexane (trans); trans-1-Fluoro-2-hydroxy-1-acetylcyclohexane; 1-Fluoro-2-hydroxy-1-cyclohexylethanone (trans); (1R,2R)-1-Fluoro-2-hydroxy-1-cyclohexylethanone; (1S,2S)-1-Fluoro-2-hydroxy-1-cyclohexylethanone; Fluorohydrin ketone intermediate; trans-Fluorohydrin cyclohexyl methyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(1-Fluoro-2-Hydroxycyclohexyl)-, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.