Description

Tris-(p-tert-Butoxyphenyl) Phosphine CAS NO 118854-31-2 is a specialized organophosphorus compound featuring a sterically hindered, electron-rich triarylphosphine structure. This molecular architecture makes it a highly effective ligand in transition metal-catalyzed cross-coupling reactions, where it facilitates key bond-forming steps with high efficiency and selectivity. It is an essential reagent for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel synthetic pathways or optimize existing ones.

Application

• Pharmaceutical Intermediate Synthesis: As a premium ligand in palladium-catalyzed reactions such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig aminations for constructing complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Employed in the catalytic synthesis of novel herbicides, fungicides, and insecticides that require precise chemical structures.
• Advanced Material Development: Used in the synthesis of organic light-emitting diodes (OLEDs), conductive polymers, and other functional materials where controlled polymerization or coupling is critical.
• Catalyst Precursor Preparation: Serves as a key component in the formulation of homogeneous catalyst systems for fine chemical and specialty chemical production.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Product Name	Tris-(p-tert-Butoxyphenyl) Phosphine
CAS No.	118854-31-2
Molecular Formula	C30H39O3P
Molecular Weight	478.60 g/mol
Synonyms	Tris(4-tert-butoxyphenyl)phosphine; Tris(p-tert-butoxyphenyl)phosphine; Phosphorous tris(4-(1,1-dimethylethoxy)phenyl); Tris(4-(tert-butoxy)phenyl)phosphine; Ligand for cross-coupling; Sterically hindered phosphine ligand; Tri(4-tert-butoxyphenyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of Tris-(p-tert-Butoxyphenyl) Phosphine is manufactured and tested under strict quality management protocols to ensure consistency and high purity for demanding synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 15-25°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep the container tightly sealed to minimize exposure to air and moisture. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.