Description

Dansyl-Platelet Activating Factor CAS NO 118790-15-1 is a high-purity, fluorescently labeled derivative of the potent phospholipid mediator, Platelet-Activating Factor (PAF). This specialized compound is critical for advanced biochemical and pharmacological research, enabling the sensitive detection and study of PAF receptors and signaling pathways. It is an essential tool for researchers and scientists in the fields of immunology, inflammation, cardiovascular disease, and cell biology who require precise molecular probes for fluorescence-based assays, microscopy, and receptor binding studies.

Application

• Fluorescence-Based Receptor Binding Assays: Used as a high-affinity fluorescent tracer to study PAF receptor (PAFR) binding kinetics, competition, and saturation in cell membranes and purified protein preparations.
• Cellular Imaging and Microscopy: Enables visualization and localization of PAF receptors in live or fixed cells using fluorescence microscopy (e.g., confocal, TIRF) to study receptor trafficking and internalization.
• Signal Transduction Research: A vital tool for investigating the role of PAF in inflammatory cascades, platelet activation, and neutrophil chemotaxis through fluorescent detection methods.
• High-Throughput Screening (HTS): Serves as a key reagent in the development of fluorescence polarization (FP) or other homogenous assays to screen for novel PAFR agonists or antagonists in drug discovery.
• Biochemical Mechanism Studies: Facilitates the study of enzyme interactions, lipid metabolism, and the molecular mechanisms underlying PAF-related pathologies.
• Diagnostic Assay Development: Used in research toward developing sensitive diagnostic tests for conditions involving dysregulated PAF signaling.

Basic Information

Product Name	Dansyl-Platelet Activating Factor
CAS No.	118790-15-1
Molecular Formula	C30H54N2O7P
Molecular Weight	594.74 g/mol
Synonyms	1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, Dansyl conjugate; Dansyl-C16 PAF; Dns-PAF; Fluorescent Platelet-Activating Factor; N-[5-(Dimethylamino)naphthalene-1-sulfonyl]-1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine; Dansyl-GPC; 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho(N-dansyl)ethanolamine
EINECS	Contact for details

Quality Control

Our Dansyl-Platelet Activating Factor is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and fluorescent labeling efficiency. Certificates of Analysis (COA) detailing purity, assay results, and spectroscopic data are provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. Solutions prepared in appropriate solvents should be used immediately or stored according to the stability of the solvent system.

Specification

Item	Specification
Appearance	Light yellow to yellow solid or film
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in chloroform, DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.