Description

Skp Protein is a crucial regulatory protein involved in the ubiquitin-proteasome pathway, essential for targeted protein degradation within cells. Its primary function in marking specific proteins for breakdown makes it a vital tool for researchers studying cell cycle regulation, signal transduction, and disease mechanisms. This high-purity biochemical is indispensable for pharmaceutical R&D, academic research in molecular biology, and the development of novel therapeutic strategies, particularly in oncology and neurodegenerative diseases.

Application

• Biochemical Research: Used as a key reagent in studies of the SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complex and protein turnover mechanisms.
• Drug Discovery & Target Validation: Essential for in vitro assays to screen and validate small molecule inhibitors targeting the ubiquitin-proteasome system for cancer therapy.
• Protein-Protein Interaction Studies: Serves as a critical component in pull-down assays, co-immunoprecipitation, and structural biology to map interaction networks.
• Cell Cycle & Signal Transduction Analysis: Employed to investigate the regulation of cell cycle progression, apoptosis, and various signaling pathways.
• Recombinant Protein Production: Used in the expression and purification of complex multi-protein assemblies for functional and structural analysis.
• Diagnostic Development: Potential use as a standard or component in developing assays for diseases linked to ubiquitin pathway dysregulation.

Basic Information

Product Name	Skp Protein
CAS No.	118549-95-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	S-phase kinase-associated protein 1; Skp1; Cyclin-A/CDK2-associated p19; p19Skp1; SCF complex subunit Skp1; E3 ubiquitin-protein ligase component; F-box protein binding protein; 19 kDa S-phase kinase-associated protein
EINECS	Contact for details

Quality Control

Our Skp Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment, identity confirmation, and functional activity assays. A detailed Certificate of Analysis (COA) is provided, confirming compliance with our rigorous internal specifications. We adhere to quality management principles suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Aliquot the product upon receipt to maintain stability and prevent contamination.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Single major band at ~19 kDa
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90% of total weight
Biological Activity (Functional Assay)	Confirmed binding to F-box proteins
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.